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w 9 cCovalent 2
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w cRecognition 2
w c 2
w cvia 2
w cIminoboronate 2
w r cChemistry
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w c @ Times New Roman - - - 2
W cJianmin Gao
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\ Y cDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA
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9 2 cMolecular recognition underlies essentially every % 2
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c / 2
cand selective inhibition 2
c 2
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cf culprit 2
9 d cmolecules has been the guiding philsophy of medicinal chemistry. In nature, seletive association of 2
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9 clargely avoided : 2
cdue to the potential difficulty 2
o c # 2
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c @ 2
# cWe and others have been developing @ Times New Roman - - - - - - - - - - - - 2
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#y c 5 2
# ccovalent chemistries, which # 2
#; ccan give rise to 2
# c R 2
#/ cpowerful strategies for targeting biomolecules. - - - 2
c1 - - - 2
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69 D cSpecifcially, we have been investigating the iminoboronate chemistry 2
6 c D 2
6& cwith the goal of targeting biological 2
H9 camines 2
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HM ciminoboronates exhibit C 2
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m8 cs 2
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mI cof the dynamic 2
m c , 2
m ciminiboronte formation 2
m\ c & 2
mh cunder physiologic 2
9 cconditions. 2
cBiological a 2
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cs 2
c : 2
cof the iminoboronate chemistry C 2
% chave been explored in our laboratory L 2
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